HORDB

ID: hor001759
Uniprot ID: P21259
Protein name: Pol-RFamide-I
Gene name: NA
Organism: Polyorchis penicillatus (Hydromedusa)
Family: FARP (FMRFamide related peptide) family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Polyorchis (genus), Polyorchidae (family), Capitata (suborder), Anthoathecata (order), Hydroidolina (subclass), Hydrozoa (class), Cnidaria (phylum), Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: QLLGGRF
Length: 7(182-188)
Propeptide: MNLITLLVLGVSTCLIYGIEADEKTSSALENEIVEILNGNFKNEKKSIETSDQWLKGRFGREVNQWLKGRFGRELSDQWLKGRFGRELSDQWLKGRFGREVLDQWLKGRFGRDASNQWLKGRFGRELSDQWLKGRFGREGSNQWLKGRFGREASKNDLEKQNGRGDSDQWLKGRFGREARKQLLGGRFGRKDMNQLLAERHGRETSDQWLKGRFGRQLSDQWLKGRFGREVKNDKNNPFRSRYTGDSTQLQRENN
Signal peptide: MNLITLLVLGVSTCLIYGIEA
Modification: T1 Pyrrolidone carboxylic acid;T7 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Function: Has direct action on motoneurons, and effect includes transient inhibition followed by prolonged excitation.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001759_AF2.pdb

hor001759_ESM.pdb

Mass:	89714	Formula:	C36H59N11O9
Absent amino acids:	ACDEHIKMNPSTVWY	Common amino acids:	GL
pI:	10.55	Basic residues:	1
Polar residues:	2	Hydrophobic residues:	3
Hydrophobicity:	22.86	Boman Index:	-576
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	111.43
Instability Index:	2620	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 2905621
Title: Isolation of pyroGlu-Leu-Leu-Gly-Gly-Arg-Phe-NH2 (Pol-RFamide), a novel neuropeptide from hydromedusae.